What Is Syn®-Ake Peptide? (Snake Venom Peptide Explained)
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What Is Syn®-Ake Peptide?
Syn®-Ake is a synthetic cosmetic peptide inspired by Waglerin-1, a peptide originally found in Temple viper venom. In skincare and cosmetic formulations, Syn®-Ake is used to help reduce the appearance of expression lines (like forehead lines and crow’s feet) by supporting a more relaxed-looking facial appearance.
Quick definition
Syn®-Ake peptide = a lab-made “snake venom-inspired” peptide used in cosmetics to soften the look of dynamic wrinkles and expression lines.
What does Syn®-Ake do?
Syn®-Ake is most commonly included in anti-aging products to target:
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Crow’s feet
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Forehead expression lines
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Smile/laughter lines (appearance)
Suppliers describe it as helping the face look more relaxed while maintaining natural expression.
Is Syn®-Ake the same as “snake venom”?
No. Syn®-Ake is a synthetic peptide (made in a lab). It is inspired by Waglerin-1, not actual venom. Waglerin-1 is known in scientific literature for interacting with muscle nicotinic acetylcholine receptors, which relates to muscle contraction signaling.
What is Syn®-Ake called on ingredient lists (INCI)?
On many ingredient lists, Syn®-Ake is associated with the INCI name:
Dipeptide Diaminobutyroyl Benzylamide Diacetate
(Brands may list it by its INCI name instead of the Syn®-Ake trademark.)
Where is Syn®-Ake used?
You’ll typically find Syn®-Ake (or its INCI name) in:
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Anti-aging serums
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Wrinkle creams
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Lifting / firming formulas
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Some hybrid makeup + skincare products
Want the full guide (benefits, safety, and Botox comparison)?
Read the complete ingredient breakdown here:
Syn®-Ake peptide guide
And if you want a practical daily-use option, explore:
Clarena Snake Fluid Foundation with Syn®-Ake